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What is the effect of a irreversible competitive antagonist on the log-concentration response curve for an agonist

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Q. What is the effect of a irreversible competitive antagonist on the log-concentration response curve for an agonist
  1. Binding Mechanism: An irreversible competitive antagonist will bind to the same site as the agonist but won't let go, which means the agonist can't bind to the receptor as effectively.
  2. Effect on Agonist Binding: Because of this, you'll need more agonist to reach the same effect, so the curve will shift to the right.
  3. Reduction in Maximum Response: The maximum response of the agonist might be reduced if the antagonist has permanently inactivated some of the receptors.
  4. Shift in Log-Concentration Curve: So, the log-concentration response curve for the agonist will shift to the right and possibly downwards if the maximum response is affected.

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